Adjuvant effect of liposome-encapsulated natural phosphodiester CpG-DNA
نویسندگان
چکیده
منابع مشابه
Enhancement of immunomodulatory activity by liposome-encapsulated natural phosphodiester bond CpG-DNA in a human B cell line.
Natural phosphodiester bond CpG-DNA that contains immunomodulatory CpG motifs (PO-DNA) upregulates the expression of proinflammatory cytokines and induces an Ag-driven Th1 response in a CG sequence-dependent manner in mice. In humans, only phosphorothioate backbone-modified CpG-DNA (PS-DNA) and not PO-DNA has immunomodulatory activity. In this study, we found that liposome-encapsulated PO-DNA u...
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ژورنال
عنوان ژورنال: BMB Reports
سال: 2011
ISSN: 1976-6696
DOI: 10.5483/bmbrep.2011.44.11.758